Penicillin cocktail

Difford's Guide
Discerning Drinkers (406 ratings)

Photographed in an

UB Koto Old Fashioned 30cl
Ingredients:
45 ml Blended Scotch whisky
15 ml Ginger liqueur
10 ml Torabhaig Peated Single Malt Whisky
20 ml Lemon juice (freshly squeezed)
20 ml Honey syrup (3 parts honey to 1 water by weight)
Loading...
× 1

Read about cocktail measures and measuring.

How to make:

  1. Select and pre-chill an Old-fashioned glass.
  2. Prepare skewered crystallised ginger for garnish.
  3. SHAKE all ingredients with ice.
  4. STRAIN into ice-filled glass (preferably over a large cube or chunk of block ice).
  5. Garnish with skewered crystallised ginger.

Strength & taste guide:


Review:

A Whisky Sour with honey richness, subtle smoke and enlivening ginger spice. A cocktail to slap the palate awake. Then you can't resist keep sipping it.

Variant:

The Penicillin cocktail originated as a riff on a Gold Rush

History:

Adapted from a 2005 recipe created by Sam Ross at Milk & Honey in Manhattan, New York City. Sam's original recipe (below) calls for ¾ oz honey-ginger syrup in place of ginger liqueur and honey.

Sam Ross's Penicillin recipe
Glass: Old-fashioned
Garnish: Skewered crystallised ginger
Method: SHAKE first 3 ingredients with ice and strain into ice-filled glass. TOP with Islay whisky.
60ml (2oz) Blended Scotch whisky
22.5ml (¾oz) Lemon juice (freshly squeezed)
22.5ml (¾oz) Honey & ginger syrup*
7.5ml (¼oz) Peated Islay single malt scotch whisky

*To make honey & ginger syrup
Peel and thinly slice 100 grams (3.5oz) of root ginger and place in a saucepan with 1 cup of honey and 1 cup of water. Bring to a boil, then reduce heat and simmer for 5 minutes. Allow to cool and place in a sealed container in a refrigerator to steep for 12 hours. Strain, bottle, and store in a refrigerator. Use within three days.

I created my version of Sam's contemporary classic, using ginger liqueur to avoid the faff of making ginger honey syrup, back in March 2009. With a good liqueur, it retains much of the ginger spice but in a more mellow form than the heat of fresh ginger juice. However, in February 2025, I came across a clutch of excellent cocktails (led by the Toreador del Diablo) made with ginger juice syrup. As to hand, I used this to create another version of the Penicillin:

Difford's Ginger Juice Syrup Penicillin
Glass: Old-fashioned
Garnish: Skewered crystallised ginger
Method: SHAKE all ingredients with ice and strain into ice-filled glass.
45ml (1½oz) Blended Scotch whisky
10ml (⅓oz) Peated single malt scotch whisky
7.5ml (¼oz) Ginger juice syrup
15ml (½oz) Honey syrup (3 honey to 1 water)
20ml (⅔oz) Lemon juice (freshly squeezed)

Nutrition:

One serving of Penicillin cocktail contains 220 calories.

Alcohol content:

  • 1.4 standard drinks
  • 17.31% alc./vol. (34.62° proof)
  • 19 grams of pure alcohol
Difford's Guide remains free-to-use thanks to the support of the brands in green above. Values stated for alcohol and calorie content, and number of drinks an ingredient makes should be considered approximate.

Join the Discussion


... comment(s) for Penicillin cocktail

You must log in to your account to make a comment.

Report comment

You must be logged in to upvote or downvote a comment

Click here to login
Welcome to Difford's Guide

All editorial and photography on this website is copyright protected

© Odd Firm of Sin 2025